A Practical Guide to Rational Drug Design by Sun Hongmao PDF
By Sun Hongmao
This booklet won't be an exhaustive survey masking all facets of rational drug layout. as a substitute, it will supply serious information via real-world examples. proper case experiences could be provided and analyzed to demonstrate the subsequent: tips on how to optimize a lead compound even if one has excessive or low degrees of structural details; how one can derive hits from rivals’ lively compounds or from typical ligands of the objectives; tips to springboard from rivals’ SAR wisdom in lead optimization; the way to layout a ligand to intervene with protein-protein interactions via accurately interpreting the PPI interface; the right way to ward off IP blockage utilizing facts mining; tips on how to build and completely make the most of a knowledge-based molecular descriptor procedure; how you can construct a competent QSAR version by means of targeting info caliber and correct choice of molecular descriptors and statistical ways. A useful consultant to Rational Drug Design specializes in computational drug layout, with purely simple assurance of biology and chemistry matters, resembling assay layout, objective validation and artificial routes.
- Discusses various tactics appropriate to day-by-day drug layout
- Readers can obtain the fabrics utilized in the publication, together with constructions, scripts, uncooked information, protocols, and codes, making this publication compatible source for brief classes or workshops
- Offers a special perspective on drug discovery examine as a result author’s cross-discipline schooling background
- Explores the author’s wealthy reports in either pharmaceutical and educational settings
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A Practical Guide to Rational Drug Design by Sun Hongmao